Description
Rhophylac IM/IV Injection 300mcg
Rhophylac IM/IV Injection 300mcg is a prescription-grade immunoglobulin product widely used in obstetric and haematological care across Pakistan. Ahmad Medico stocks the original Rhophylac inj in its 1 pre-filled syringe (PFS) x 2ml presentation, so you get the exact dose your doctor prescribes, delivered to your doorstep without compromising cold-chain integrity.
What Is Rhophylac?
Rhophylac is a human anti-D immunoglobulin manufactured by CSL Behring, a globally recognised biologics company. Each 2ml pre-filled syringe contains 300 mcg (1,500 IU) of polyclonal anti-D (Rho) immunoglobulin, derived from human plasma. The formulation is suitable for both intramuscular (IM) and intravenous (IV) administration, which gives clinicians flexibility depending on the clinical situation and the patient’s condition.
The core mechanism is straightforward: Rhophylac anti-D works by binding to Rh(D)-positive red blood cells. This prevents the immune system of an Rh(D)-negative individual from recognising those cells as foreign and producing its own anti-D antibodies, a process called Rh sensitisation.
Rhophylac 300mcg Injection Uses
Rhophylac 300mcg injection has two primary licensed indications:
1. Prevention of Rh(D) Sensitisation in Rh(D)-Negative Women
This is the most common reason doctors prescribe Rhophylac in Pakistan. When an Rh(D)-negative mother carries an Rh(D)-positive baby, small amounts of foetal blood can enter the maternal circulation. Without prophylaxis, the mother’s immune system may produce anti-D antibodies. In a subsequent pregnancy, those antibodies can cross the placenta and attack the baby’s red blood cells, a potentially life-threatening condition known as haemolytic disease of the foetus and newborn (HDFN).
Rhophylac prevents this. Your doctor may prescribe it in the following scenarios:
- Antenatal prophylaxis: typically administered around 28–34 weeks of pregnancy
- Postpartum prophylaxis: within 72 hours of delivering an Rh(D)-positive baby
- Following sensitising events: miscarriage, ectopic pregnancy, termination of pregnancy, amniocentesis, chorionic villus sampling (CVS), external cephalic version, or abdominal trauma during pregnancy
2. Treatment of Immune Thrombocytopenic Purpura (ITP)
In Rh(D)-positive, non-splenectomised patients, Rhophylac can be used to increase platelet counts in immune thrombocytopenic purpura (ITP). For this indication, IV administration is required. Your haematologist will determine whether Rhophylac is the right option based on your full clinical picture.
Where to Give Rhophylac Injection?
The injection site depends on the route your doctor specifies:
- Intramuscular (IM): The deltoid muscle of the upper arm or the anterolateral thigh is the preferred site. The gluteal region is generally avoided for IM immunoglobulin injections due to variable absorption.
- Intravenous (IV): Administered via slow IV infusion. This route is mandatory when Rhophylac is used for ITP treatment and may be preferred when large volumes need to be given rapidly following a significant foetal-maternal haemorrhage.
Always follow your healthcare provider’s instructions on administration route, site, and technique. Self-administration without medical supervision is not recommended.
Rhophylac Injection Side Effects
Like all immunoglobulin products, Rhophylac injection can cause side effects, although serious reactions are uncommon. You should be aware of the following:
Common side effects:
- Pain, swelling, or redness at the injection site
- Mild fever
- Headache
- Fatigue or malaise
Less common but notable:
- Nausea
- Chills
- Joint or muscle pain
Rare but serious:
- Hypersensitivity or allergic reactions, including anaphylaxis, particularly in individuals with IgA deficiency who carry anti-IgA antibodies
- Haemolysis (breakdown of red blood cells), reported particularly with IV use in ITP patients
- Disseminated intravascular coagulation (DIC) is an extremely rare but documented risk with IV administration in ITP patients
If you notice difficulty breathing, rapid heartbeat, dizziness, or severe swelling after receiving the injection, seek emergency medical attention immediately. Your doctor should always administer the first dose in a setting where anaphylaxis can be managed.
Dosage and Important Prescribing Notes
The standard dose for routine antenatal and postnatal prophylaxis is 300 mcg injection (1,500 IU), which corresponds to one full 2ml pre-filled syringe. In cases of large foetomaternal haemorrhage (confirmed by Kleihauer-Betke test or flow cytometry), additional doses may be required.
For ITP, dosing is weight-based and determined by the treating haematologist. Rhophylac is not for self-prescribing; its use requires a valid prescription and clinical oversight.
Storage: Store between 2°C and 8°C. Do not freeze. Keep away from direct light. Ahmad Medico maintains proper cold-chain conditions throughout storage and dispatch to ensure the product reaches you in full potency.
Buy Rhophylac Injection Online in Pakistan
Ahmad Medico is one of the few verified platforms where you can buy anti-D injection online in Pakistan with confidence. Whether you’re searching for rhophylac injection price in Pakistan or need urgent access to the product in a scheduled antenatal appointment, Ahmad Medico provides:
- Original, manufacturer-sourced stock, no counterfeit risk
- Cold-chain compliant dispatch
- Transparent pricing, check the current Rhophylac 300mg price in Pakistan directly on the product page
- Fast delivery across major cities, including Karachi, Lahore, Islamabad, and Rawalpindi
To place your order, upload your prescription during checkout or contact Ahmad Medico’s pharmacy team for guidance. Your health decisions should always rest on verified information and legitimate sourcing, and that is exactly what Ahmad Medico stands for.
