Octagam 2.5g/50ml Injection (immunoglobulin G)

Description

Octagam 2.5g/50ml Injection – Your Trusted Solution for Immune Deficiencies

Octagam 2.5g/50ml Injection is a sterile, ready-to-use IVIG solution manufactured by Octapharma AG, a global leader in plasma-derived therapies. Each vial contains 2.5 grams of highly purified human immunoglobulin G (IgG) antibodies in a 50 mL solution. This product is designed for intravenous infusion and is indicated for patients with antibody deficiency who require immune system support to fight infections and regulate immune response.

• Main Ingredient: Human normal immunoglobulin G (IgG), ≥95% purity
• Formulation: Clear to slightly opalescent, colorless to slightly yellow solution
• Stabilizer: Maltose (no sucrose, no preservatives, latex-free)
• Source: Plasma from healthy human donors

Octagam Price in Pakistan

You can find Octagam 2.5g/50ml Injection at Ahmed Medico and other leading online pharmacies in Pakistan. The price typically ranges from Rs. 17,000 to Rs. 27,000 per vial, depending on the supplier and location. Ahmed Medico ensures proper cold chain management and authentic supply for your safety and peace of mind.

Who Needs Octagam? – Medical Indications

Octagam 2.5g Injection is prescribed for a range of immune deficiencies and autoimmune disorders, including:

Primary Immunodeficiencies (PID):

• X-linked agammaglobulinemia
• Congenital agammaglobulinemia
• Common variable immunodeficiency
• Wiskott-Aldrich syndrome
• Severe combined immunodeficiencies

Autoimmune Disorders:

• Chronic immune thrombocytopenic purpura (ITP)
• Guillain-Barré Syndrome
• Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
• Kawasaki Disease

Octagam provides essential antibody replacement for patients who cannot produce enough IgG antibodies, reducing the risk of recurrent and severe infections and helping regulate immune response in autoimmune conditions.

How Octagam Works: Mechanism of Action

Octagam supplies your body with functional IgG antibodies, which:

• Bind to and neutralize bacteria and viruses, helping you fight infections
• Mark pathogens for destruction by your immune system
• Modulate immune activity, reducing harmful inflammation in autoimmune disorders

This dual action makes Octagam vital for both antibody deficiency and immune system regulation.

Dosage, Infusion, and Administration

Your healthcare provider calculates your dosage based on your body weight and medical condition:

• Standard Dose: 300–600 mg/kg body weight (6-12 mL/kg) per infusion
• Initial Dose: Usually within this range, followed by a maintenance dose every 3-4 weeks

Infusion Protocol:

• Start at 0.5 mg/kg/min for the first 30 minutes
• Gradually increase to 1 mg/kg/min, then 2 mg/kg/min, up to a maximum of 3.33 mg/kg/min if tolerated
• For patients with kidney problems or blood clotting risks, do not exceed 0.07 mL/kg/min

Administration Tips:

• Infuse at room temperature
• Flush the line with normal saline (0.9% saline) or 5% dextrose in water before and after administration.
• Do not mix with other medications in the same line

Safety, Side Effects, and Precautions

Octagam is generally well tolerated, but you should be aware of possible side effects:

Common Side Effects	Serious Risks (Rare)
Headache, fever, chills	Hypersensitivity reactions, anaphylaxis
Nausea, vomiting	Blood clotting risks (thrombosis, DVT, pulmonary embolism)
Muscle aches and pains	Kidney problems, acute kidney injury
Skin reactions, back pain	Chest pain, joint pain, and insomnia
Dizziness, injection site reactions

• Infusion reactions may occur, especially with rapid rates or first-time use. Your medical team will monitor you closely.
• Hypersensitivity reactions and anaphylaxis are rare but require immediate medical attention.
• Blood clotting risks and kidney problems are more likely in patients with predisposing conditions.
• Pregnancy and breastfeeding: Use only if clearly needed and prescribed by your doctor.

Storage and Compatibility

• Store Octagam at 2°C to 8°C (do not freeze)
• Compatible with normal saline (0.9% saline) and 5% dextrose in water for flushing
• Do not mix with other drugs in the same infusion set

Frequently Asked Questions

What is an Octagam 2.5g Injection?

Octagam 2.5g Injection is an intravenous immunoglobulin containing 2.5 grams of highly purified human IgG antibodies in a 50 mL solution, used for treating immune deficiencies and autoimmune disorders.

Can I Buy Octagam 2.5g Injection Online in Pakistan?

Yes, you can purchase Octagam 2.5g Injection online through licensed Pakistani pharmacies like Ahmed Medico, requiring a valid prescription from your registered healthcare provider.

Is Octagam a chemo drug?

No, Octagam is not chemotherapy. It is an immunoglobulin therapy derived from human plasma, used for antibody replacement and immune modulation, not cancer treatment.

How long does an Octagam infusion take?

Octagam infusions typically last 2–5 hours, starting slowly and gradually increasing rate based on your tolerance. Duration depends on the prescribed dose and individual response.

Is Octagam safe?

Octagam is generally safe under medical supervision but can cause side effects, including headache, fever, nausea, and rarely serious complications like thrombosis or kidney injury.

What is the new indication of Octagam?

The newest FDA-approved indication for Octagam 10% is adult dermatomyositis treatment, a rare autoimmune muscle disease, based on clinical trial evidence of efficacy.

Is Octagam a blood product?

Yes, Octagam is classified as a blood product manufactured from pooled human plasma containing immunoglobulin G antibodies essential for immune system function.

Does Octagam cause weight gain?

Weight gain is not a common side effect of Octagam. However, rapid weight gain may indicate fluid retention requiring immediate medical attention and evaluation.

Does Octagam have sugar?

Octagam contains maltose, a corn-derived sugar used as stabilizer. Unlike some products, it does not contain sucrose, reducing certain kidney complication risks.

Is Octagam FDA-approved?

Yes, Octagam has FDA approval for primary humoral immunodeficiency treatment and other specific indications, meeting rigorous safety and efficacy standards for patient use.

Is Octagam compatible with normal saline?

Yes, Octagam is fully compatible with normal saline (0.9% sodium chloride) and 5% dextrose in water for infusion line flushing before and after administration.