Prolia 60 mg solution for injection in pre-filled syringe




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Prolia 60 mg solution for injection in pre-filled syringe

Prolia (denosumab) is a medication primarily used to treat osteoporosis in postmenopausal women and in men at increased risk of fractures. It belongs to a class of drugs called monoclonal antibodies, which work by blocking a specific protein (RANK ligand) involved in the breakdown of bone tissue. By inhibiting this protein, Prolia helps to increase bone density and reduce the risk of fractures.

Here are some key points about Prolia:

  1. Mechanism of Action: Denosumab, the active ingredient in Prolia, binds to RANK ligand, which is a protein involved in the formation, function, and survival of osteoclasts (cells that break down bone tissue). By inhibiting RANK ligand, Prolia reduces bone resorption and increases bone mass and strength.
  2. Indications: Prolia is primarily prescribed for the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It is also used to increase bone mass in men with osteoporosis at high risk for fracture and to treat bone loss in individuals undergoing hormone ablation therapy for prostate or breast cancer.
  3. Administration: Prolia is administered as a subcutaneous injection (under the skin) once every six months. It is usually given by a healthcare professional in a clinical setting.
  4. Efficacy: Clinical studies have shown that Prolia significantly reduces the risk of vertebral, non-vertebral, and hip fractures in individuals with osteoporosis. It also improves bone mineral density and reduces bone turnover markers.
  5. Safety: Like all medications, Prolia may cause side effects. Common side effects include back pain, pain in extremities, musculoskeletal pain, high cholesterol, and urinary tract infections. Serious side effects may include osteonecrosis of the jaw (jaw bone death) and atypical femoral fractures. Patients should discuss the risks and benefits of Prolia with their healthcare provider.
  6. Monitoring: While taking Prolia, patients may need periodic monitoring of their calcium levels. It is important for patients to follow up with their healthcare provider regularly to assess the response to treatment and monitor for any potential side effects.
  7. Contraindications: Prolia should not be used in individuals with hypocalcemia (low blood calcium levels) and those with a history of hypersensitivity to denosumab or any of the components of the medication.


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